Resorbable Filling Substances 2

Resorbable Filling Substances

Perlane® New Jersey

The Plastic Surgery Group is one of the first providers in the region to offer Perlane® to their patients. The makers of Restylane® recently received FDA approval for their next generation product, Perlane®. Perlane® is made from the same natural, biocompatible substance as Restylane®, but the particles are larger, making the gel thicker. This allows our doctors to achieve a deeper, smoother correction that may potentially be longer lasting! The most common areas that Perlane® is used to correct are the nasolabial folds, the areas around the mouth as well as in the tear troughs (the hollows under the eyes). Results are immediate!

Hylaform and Hylaform Plus New Jersey

Hylaform and Hylaform Plus are hyaluronic acids that are similar to Restylane®. Hylaform Plus has a larger particle size and is designed for deeper creases. A study comparing the duration of correction for Hylaform Plus and Restylane® has been conducted and the findings will be presented in the near future. For now, it is safe to say that most plastic surgeons tell patients to expect three or four months of correction from Hylaform.

Captique New Jersey

Captique is basically the same as Hylaform with the major difference that it is manufactured rather than harvested from rooster combs. This allows the product to be produced without any animal proteins that theoretically can cause allergic reactions. It is the same concentration and thickness as Hylaform, and it is reasonable to assume it will have the same longevity.

Other Hyaluronic Acid Based Products Under Development

Juvderm has been used in Europe and is a major step forward for the hyaluronic acid fillers. It is a homogenous gel that does not contain gel particles. It is manufactured and is not derived from animals. Three versions are presently available and they are well suited to a broad range of applications. There are three varieties of Juvaderm 18, 24, and 30 that vary in the concentration of hyaluronic acid contained. The variety of concentrations allows a broad range of uses for this filler ranging from filling crow’s feet with a less dense product to smoothing nasal furrows with a more dense variety. Juvaderm is currently undergoing clinical trials in the United States.

“You never want to be the first one on your block to try a new technique or procedure. Wait until it has been fully evaluated.”

Poly-L-Lactic Acid

Developed by a French dermatologist, Sculptra is based on a substance called poly-L-lactic acid (PLA) which occurs naturally and has been used in suture material for years. PLA stimulates production of the body’s own collagen within the line or wrinkle, making the skin appear smoother and firmer. Sculptra is reconstituted before it is injected and is most commonly used in the nasal labial folds, cheek hollows and scars. The substance is non-allergenic and typically two to three treatment sessions are recommended for best results.

Human Tissue Fillers

One of the fascinating categories of filling agents is derived from human tissue. Most of these products are obtained from cadaver tissue through tissue banks. Donor suitability is determined according to the standards of the American Association of Tissue Banks (MTB) and FDA. Cadaver collagen must meet criteria established for extensive testing for human immunodeficiency virus antibody (anti-HIV 1-2), Hepatitis B surface antigen (HBsAG), Hepatitis B core antibody (HBcAB), Hepatitis C antibody (anti HCV), human T-lymphotropic virus type I antibody (anti HTLV-1), and rapid plasma regain (RPR) for syphilis.

Cosmoderm® New Jersey /Cosmoplast® New Jersey

CosmoDerm® and CosmoPlast® (Inamed Corp) contains human collagen that has been purified from a single fibroblast cell culture. This product does contain 0.3% lidocaine, so additional local anesthesia is usually not required. No skin test is required because this is fashioned from human tissues rather than an animal source. CosmoDerm® and CosmoPlast® are injected just below the surface of the skin to fill in superficial lines and wrinkles and to define the border of the lips.

Alloderm® New Jersey / Cymetra New Jersey

AlloDerm® is human dermal tissue that has been decellularized to remove the risk of rejection or inflammation. It comes in strips in a freeze dried form to be implanted into lips, nasal defects, and around the eyelids. AlloDerm® is sometimes used as a soft-tissue replacement in facial reconstruction to build up cheeks, chins, hollows and asymmetries. It can be rolled or layered so that it can be implanted under the skin to fill out depressions. Cymetra was introduced in 2000. It is micronized AlloDerm® tissue in an injectable form. It also needs to be reconstituted. More than one treatment may be required to achieve the level of correction envisioned. AlloDerm® may last up to two years; Cymetra may last two to four months.

“The key with soft tissue fillers is to select a safe product that has a long track record.”