Zyderm and Zyplast (Inamed Corp) are composed of highly purified bovine dermal collagen that has been used to correct facial imperfections since the 1980’s. The bovine collagen is processed to create a product that is similar to human collagen. There are three forms: Zyderm 1, Zyderm 2, and Zyplast. Four weeks prior to the procedure, a test dose is administered in the forearm to determine if you have a sensitivity to the implant material. Three percent of people tested may have sensitivities. Frequently a second test dose is administered. Collagen is most commonly used to fill out superficial wrinkles, skin depressions and some scars. It has been largely replaced by newer substances including human collagen and hyaluronic acid gel.
Restylane, Perlane, and Restylane Touch are all the same material packaged in a different particle size. Perlane has a large particle size while the size of Restylane particles is small. We use the larger particles when I need to fill deep wrinkles and the smaller ones when I need to fill superficial ones. We have been surprisingly pleased with this family of products and our patients love the variety and durability that they offer.
Restylane is the only product presently approved by the FDA for use in the United States; however since Perlane and Restylane Touch are the exact same molecule, they will hopefully be approved soon. We use Restylane to treat nasolabial creases (smile lines) most commonly but it can also be used for other deep creases around the mouth and between the eyebrow when BOTOX is not effective. Perlane is great for restoring volume. It is used for deep creases including the nasolabial creases and for facial sculpting.
“You never want to be the first one on your block to try a new technique or procedure. Wait until it has been fully evaluated.”
“The key with soft tissue fillers is to select a safe product that has a long track record.”